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Peripheral eosinophil counts predict efficacy of anti-CD19 CAR-T cell therapy against B-lineage non-Hodgkin lymphoma.
Theranostics. 2021; 11(10):4699-4709.
Jia Q, Qin D, He F, Xie Q, Ying Z, Zhang Y, Song Y, Cheng JN, Zuo X, Xu L, Fang H, Hu C, Peng L, Jin T, Shi Z, Alexander PB, Wang Y, Liu Y, Han W, Zhu J, Wang P, Li QJ, Zhu B.
PMID: 33754022.
ERK Activation in CAR T Cells Is Amplified by CD28-Mediated Increase in CD3ζ Phosphorylation.
iScience. 2020 Apr 24; 23(4):101023.
Rohrs JA, Siegler EL, Wang P, Finley SD.
PMID: 32325413.
Donor-Derived CD123-Targeted CAR T Cell Serves as a RIC Regimen for Haploidentical Transplantation in a Patient With FUS-ERG+ AML.
Front Oncol. 2019; 9:1358.
Yao S, Jianlin C, Yarong L, Botao L, Qinghan W, Hongliang F, Lu Z, Hongmei N, Pin W, Hu C, Liangding H, Bin Z.
PMID: 31850234.
Quantitative Proteomics and Metabolomics Reveal Biomarkers of Disease as Potential Immunotherapy Targets and Indicators of Therapeutic Efficacy.
Theranostics. 2019; 9(25):7872-7888. MacMullan MA, Dunn ZS, Graham N, Yang L, Wang P.
PMID: 31695805.
T cell immunotherapy enhanced by designer biomaterials.
Biomaterials. 2019 10; 217:119265.
Dunn ZS, Mac J, Wang P.
PMID: 31271861.
Inhibition of nucleotide synthesis promotes replicative senescence of human mammary epithelial cells.
J Biol Chem. 2019 07 05; 294(27):10564-10578.
Delfarah A, Parrish S, Junge JA, Yang J, Seo F, Li S, Mac J, Wang P, Fraser SE, Graham NA.
PMID: 31138644.
Evaluating CAR-T Cell Therapy in a Hypoxic 3D Tumor Model.
Adv Healthc Mater. 2019 03; 8(5):e1900001.
Ando Y, Siegler EL, Ta HP, Cinay GE, Zhou H, Gorrell KA, Au H, Jarvis BM, Wang P, Shen K.
PMID: 30734529.
Understanding the Dynamics of T-Cell Activation in Health and Disease Through the Lens of Computational Modeling.
JCO Clin Cancer Inform. 2019 01; 3:1-8.
Rohrs JA, Wang P, Finley SD.
PMID: 30689404.
Computational Model of Chimeric Antigen Receptors Explains Site-Specific Phosphorylation Kinetics.
Biophys J. 2018 09 18; 115(6):1116-1129.
Rohrs JA, Zheng D, Graham NA, Wang P, Finley SD.
PMID: 30197180.
Off-the-Shelf CAR-NK Cells for Cancer Immunotherapy.
Cell Stem Cell. 2018 08 02; 23(2):160-161.
Siegler EL, Zhu Y, Wang P, Yang L.
PMID: 30075127.
TAK1 mediates microenvironment-triggered autocrine signals and promotes triple-negative breast cancer lung metastasis.
Nat Commun. 2018 05 18; 9(1):1994.
Iriondo O, Liu Y, Lee G, Elhodaky M, Jimenez C, Li L, Lang J, Wang P, Yu M.
PMID: 29777109.
CAR-T Cells Surface-Engineered with Drug-Encapsulated Nanoparticles Can Ameliorate Intratumoral T-cell Hypofunction.
Cancer Immunol Res. 2018 07; 6(7):812-824.
Siriwon N, Kim YJ, Siegler E, Chen X, Rohrs JA, Liu Y, Wang P.
PMID: 29720380.
Preclinical Models in Chimeric Antigen Receptor-Engineered T-Cell Therapy.
Hum Gene Ther. 2018 05; 29(5):534-546.
Siegler EL, Wang P.
PMID: 29390873.
In Vivo Expansion and Antitumor Activity of Coinfused CD28- and 4-1BB-Engineered CAR-T Cells in Patients with B Cell Leukemia.
Mol Ther. 2018 04 04; 26(4):976-985.
Cheng Z, Wei R, Ma Q, Shi L, He F, Shi Z, Jin T, Xie R, Wei B, Chen J, Fang H, Han X, Rohrs JA, Bryson P, Liu Y, Li QJ, Zhu B, Wang P.
PMID: 29503204.
Enhanced Cancer Immunotherapy by Chimeric Antigen Receptor-Modified T Cells Engineered to Secrete Checkpoint Inhibitors.
Clin Cancer Res. 2017 Nov 15; 23(22):6982-6992.
Li S, Siriwon N, Zhang X, Yang S, Jin T, He F, Kim YJ, Mac J, Lu Z, Wang S, Han X, Wang P.
PMID: 28912137.
Breast cancer vaccines delivered by dendritic cell-targeted lentivectors induce potent antitumor immune responses and protect mice from mammary tumor growth.
Vaccine. 2017 10 13; 35(43):5842-5849.
Bryson PD, Han X, Truong N, Wang P. PMID: 28916248.
Combination Cancer Therapy Using Chimeric Antigen Receptor-Engineered Natural Killer Cells as Drug Carriers.
Mol Ther. 2017 Dec 06; 25(12):2607-2619.
Siegler EL, Kim YJ, Chen X, Siriwon N, Mac J, Rohrs JA, Bryson PD, Wang P.
PMID: 28919377.
Dendritic cell-targeted lentiviral vector immunization uses pseudotransduction and DNA-mediated STING and cGAS activation.
Sci Immunol. 2017 Jul 21; 2(13).
Kim JT, Liu Y, Kulkarni RP, Lee KK, Dai B, Lovely G, Ouyang Y, Wang P, Yang L, Baltimore D.
PMID: 28733470.
Adnectin-Based Design of Chimeric Antigen Receptor for T Cell Engineering.
Mol Ther. 2017 11 01; 25(11):2466-2476.
Han X, Cinay GE, Zhao Y, Guo Y, Zhang X, Wang P.
PMID: 28784559.
Designed Ankyrin Repeat Proteins as Her2 Targeting Domains in Chimeric Antigen Receptor-Engineered T Cells.
Hum Gene Ther. 2017 09; 28(9):726-736.
Siegler E, Li S, Kim YJ, Wang P.
PMID: 28796529.
Co-delivery of carboplatin and paclitaxel via cross-linked multilamellar liposomes for ovarian cancer treatment.
RSC Adv. 2017 Apr 03; 7(32):19685-19693.
Zhang X, Liu Y, Kim YJ, Mac J, Zhuang R, Wang P.
PMID: 28603607.
Masked Chimeric Antigen Receptor for Tumor-Specific Activation.
Mol Ther. 2017 01 04; 25(1):274-284.
Han X, Bryson PD, Zhao Y, Cinay GE, Li S, Guo Y, Siriwon N, Wang P.
PMID: 28129121.
Directed Evolution of Scanning Unnatural-Protease-Resistant (SUPR) Peptides for in Vivo Applications.
Chembiochem. 2016 09 02; 17(17):1643-51.
Fiacco SV, Kelderhouse LE, Hardy A, Peleg Y, Hu B, Ornelas A, Yang P, Gammon ST, Howell SM, Wang P, Takahashi TT, Millward SW, Roberts RW.
PMID: 27465925.
Predictive Model of Lymphocyte-Specific Protein Tyrosine Kinase (LCK) Autoregulation.
Cell Mol Bioeng. 2016; 9:351-367.
Rohrs JA, Wang P, Finley SD.
PMID: 27547268.
A multi-antigen vaccine in combination with an immunotoxin targeting tumor-associated fibroblast for treating murine melanoma.
Mol Ther Oncolytics. 2016; 3:16007.
Fang J, Hu B, Li S, Zhang C, Liu Y, Wang P.
PMID: 27119119.
A potent immunotoxin targeting fibroblast activation protein for treatment of breast cancer in mice.
Int J Cancer. 2016 Feb 15; 138(4):1013-23.
Fang J, Xiao L, Joo KI, Liu Y, Zhang C, Liu S, Conti PS, Li Z, Wang P.
PMID: 26334777.
Co-Eradication of Breast Cancer Cells and Cancer Stem Cells by Cross-Linked Multilamellar Liposomes Enhances Tumor Treatment.
Mol Pharm. 2015 Aug 03; 12(8):2811-22.
Kim YJ, Liu Y, Li S, Rohrs J, Zhang R, Zhang X, Wang P.
PMID: 26098197.
Generation of Targeted Adeno-Associated Virus (AAV) Vectors for Human Gene Therapy.
Curr Pharm Des. 2015; 21(22):3248-56.
Liu Y, Siriwon N, Rohrs JA, Wang P.
PMID: 26027561.
Pseudotyping lentiviral vectors with lymphocytic choriomeningitis virus glycoproteins for transduction of dendritic cells and in vivo immunization.
Hum Gene Ther Methods. 2014 Dec; 25(6):328-38.
Zhang C, Hu B, Xiao L, Liu Y, Wang P.
PMID: 25416034.
Codelivery of chemotherapeutics via crosslinked multilamellar liposomal vesicles to overcome multidrug resistance in tumor.
PLoS One. 2014; 9(10):e110611.
Liu Y, Fang J, Joo KI, Wong MK, Wang P.
PMID: 25330237.
Clickable protein nanocapsules for targeted delivery of recombinant p53 protein.
J Am Chem Soc. 2014 Oct 29; 136(43):15319-25.
Zhao M, Liu Y, Hsieh RS, Wang N, Tai W, Joo KI, Wang P, Gu Z, Tang Y.
PMID: 25289975.
In situ modulation of dendritic cells by injectable thermosensitive hydrogels for cancer vaccines in mice.
Biomacromolecules. 2014 Oct 13; 15(10):3836-45.
Liu Y, Xiao L, Joo KI, Hu B, Fang J, Wang P.
PMID: 25207465.
Serum stable natural peptides designed by mRNA display.
Sci Rep. 2014 Sep 19; 4:6008.
Howell SM, Fiacco SV, Takahashi TT, Jalali-Yazdi F, Millward SW, Hu B, Wang P, Roberts RW.
PMID: 25234472.
Codelivery of doxorubicin and paclitaxel by cross-linked multilamellar liposome enables synergistic antitumor activity.
Mol Pharm. 2014 May 05; 11(5):1651-61.
Liu Y, Fang J, Kim YJ, Wong MK, Wang P.
PMID: 24673622.
Enhancing gene delivery of adeno-associated viruses by cell-permeable peptides.
Mol Ther Methods Clin Dev. 2014; 1:12.
Liu Y, Kim YJ, Ji M, Fang J, Siriwon N, Zhang LI, Wang P.
PMID: 26015948.
Passive immunization against HIV/AIDS by antibody gene transfer.
Viruses. 2014 Jan 27; 6(2):428-47.
Yang L, Wang P.
PMID: 24473340.
Visualization of intracellular pathways of engineered baculovirus in mammalian cells.
Virus Res. 2014 Mar 06; 181:81-91.
Liu Y, Joo KI, Lei Y, Wang P.
PMID: 24457070.
Advances and challenges in the use of nanoparticles to optimize PK/PD interactions of combined anti-cancer therapies.
Curr Drug Metab. 2014; 15(8):818-28.
Liu Y, Rohrs J, Wang P.
PMID: 25705903.
Synthetic niches for differentiation of human embryonic stem cells bypassing embryoid body formation.
J Biomed Mater Res B Appl Biomater. 2014 Jul; 102(5):1101-12.
Liu Y, Fox V, Lei Y, Hu B, Joo KI, Wang P.
PMID: 24327412.
Visualization of DC-SIGN-mediated entry pathway of engineered lentiviral vectors in target cells.
PLoS One. 2013; 8(6):e67400.
Liu Y, Tai A, Joo KI, Wang P.
PMID: 23840690.
A tetracycline-regulated cell line produces high-titer lentiviral vectors that specifically target dendritic cells.
J Vis Exp. 2013 Jun 19; (76).
Bryson PD, Zhang C, Lee CL, Wang P.
PMID: 23851977.
Enhanced therapeutic efficacy of iRGD-conjugated crosslinked multilayer liposomes for drug delivery.
Biomed Res Int. 2013; 2013:378380.
Liu Y, Ji M, Wong MK, Joo KI, Wang P.
PMID: 23691500.
Antibody-mimetic ligand selected by mRNA display targets DC-SIGN for dendritic cell-directed antigen delivery.
ACS Chem Biol. 2013 May 17; 8(5):967-77.
Xiao L, Hung KC, Takahashi TT, Joo KI, Lim M, Roberts RW, Wang P.
PMID: 23427768.
Genome mining of a prenylated and immunosuppressive polyketide from pathogenic fungi.
Org Lett. 2013 Feb 15; 15(4):780-3.
Chooi YH, Fang J, Liu H, Filler SG, Wang P, Tang Y.
PMID: 23368997.
Crosslinked multilamellar liposomes for controlled delivery of anticancer drugs.
Biomaterials. 2013 Apr; 34(12):3098-109.
Joo KI, Xiao L, Liu S, Liu Y, Lee CL, Conti PS, Wong MK, Li Z, Wang P.
PMID: 23375392.
Dendritic cell-directed vaccination with a lentivector encoding PSCA for prostate cancer in mice.
PLoS One. 2012; 7(11):e48866.
Xiao L, Joo KI, Lim M, Wang P.
PMID: 23139820.
Site-specific modification of adeno-associated viruses via a genetically engineered aldehyde tag.
Small. 2013 Feb 11; 9(3):421-9.
Liu Y, Fang Y, Zhou Y, Zandi E, Lee CL, Joo KI, Wang P.
PMID: 23038676.
Discovery and characterization of a group of fungal polycyclic polyketide prenyltransferases.
J Am Chem Soc. 2012 Jun 06; 134(22):9428-37.
Chooi YH, Wang P, Fang J, Li Y, Wu K, Wang P, Tang Y.
PMID: 22590971.
Endocytic processing of adeno-associated virus type 8 vectors for transduction of target cells.
Gene Ther. 2013 Mar; 20(3):308-17.
Liu Y, Joo KI, Wang P.
PMID: 22622241.
PD-1/PD-L1 blockade can enhance HIV-1 Gag-specific T cell immunity elicited by dendritic cell-directed lentiviral vaccines.
Mol Ther. 2012 Sep; 20(9):1800-9.
Dai B, Xiao L, Bryson PD, Fang J, Wang P.
PMID: 22588271.
A TLR4 agonist synergizes with dendritic cell-directed lentiviral vectors for inducing antigen-specific immune responses.
Vaccine. 2012 Mar 28; 30(15):2570-81.
Xiao L, Kim J, Lim M, Dai B, Yang L, Reed SG, Baltimore D, Wang P.
PMID: 22314134.
Construction of stable producer cells to make high-titer lentiviral vectors for dendritic cell-based vaccination.
Biotechnol Bioeng. 2012 Jun; 109(6):1551-60.
Lee CL, Chou M, Dai B, Xiao L, Wang P.
PMID: 22179950.
Engineered lentiviral vectors pseudotyped with a CD4 receptor and a fusogenic protein can target cells expressing HIV-1 envelope proteins.
Virus Res. 2011 Sep; 160(1-2):340-50.
Lee CL, Dang J, Joo KI, Wang P.
PMID: 21802459.
Virus-receptor mediated transduction of dendritic cells by lentiviruses enveloped with glycoproteins derived from Semliki Forest virus.
PLoS One. 2011; 6(6):e21491.
Froelich S, Tai A, Kennedy K, Zubair A, Wang P.
PMID: 21738680.
Pseudotyping lentiviral vectors with aura virus envelope glycoproteins for DC-SIGN-mediated transduction of dendritic cells.
Hum Gene Ther. 2011 Oct; 22(10):1281-91.
Froelich S, Tai A, Kennedy K, Zubair A, Wang P.
PMID: 21452926.
Redox-responsive nanocapsules for intracellular protein delivery.
Biomaterials. 2011 Aug; 32(22):5223-30.
Zhao M, Biswas A, Hu B, Joo KI, Wang P, Gu Z, Tang Y.
PMID: 21514660.
Enhanced real-time monitoring of adeno-associated virus trafficking by virus-quantum dot conjugates.
ACS Nano. 2011 May 24; 5(5):3523-35.
Joo KI, Fang Y, Liu Y, Xiao L, Gu Z, Tai A, Lee CL, Tang Y, Wang P.
PMID: 21473596.
Dendritic cell-directed lentivector vaccine induces antigen-specific immune responses against murine melanoma.
Cancer Gene Ther. 2011 May; 18(5):370-80.
Yang HG, Hu BL, Xiao L, Wang P.
PMID: 21372855.
Gene editing of human embryonic stem cells via an engineered baculoviral vector carrying zinc-finger nucleases.
Mol Ther. 2011 May; 19(5):942-50.
Lei Y, Lee CL, Joo KI, Zarzar J, Liu Y, Dai B, Fox V, Wang P.
PMID: 21326219.
Production of lentiviral vectors with enhanced efficiency to target dendritic cells by attenuating mannosidase activity of mammalian cells.
J Biol Eng. 2011 Jan 28; 5(1):1. Tai A,
Froelich S, Joo KI, Wang P.
PMID: 21276219.
Endoprotease-mediated intracellular protein delivery using nanocapsules.
ACS Nano. 2011 Feb 22; 5(2):1385-94.
Biswas A, Joo KI, Liu J, Zhao M, Fan G, Wang P, Gu Z, Tang Y.
PMID: 21268592.
Immunization delivered by lentiviral vectors for cancer and infectious diseases.
Immunol Rev. 2011 Jan; 239(1):45-61.
Hu B, Tai A, Wang P.
PMID: 21198664.
Batch fabrication of high-performance planar patch-clamp devices in quartz.
Adv Mater .2010 Nov 02; 22(41):4622-7.
Nagarah JM, Paek E, Luo Y, Wang P, Hwang GS, Heath JR.
PMID: 20830714.
Imaging multiple intermediates of single-virus membrane fusion mediated by distinct fusion proteins.
Microsc Res Tech. 2010 Sep; 73(9):886-900.
Joo KI, Tai A, Lee CL, Wong C, Wang P.
PMID: 20232362.
Vaccines delivered by integration-deficient lentiviral vectors targeting dendritic cells induces strong antigen-specific immunity.
Vaccine. 2010 Sep 24; 28(41):6675-83.
Hu B, Dai B, Wang P.
PMID: 20709004.
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Probing protease activity by single-fluorescent-protein nanocapsules.
Chem Commun (Camb). 2010 Sep 21; 46(35):6467-9.
Gu Z, Biswas A, Joo KI, Hu B, Wang P, Tang Y.
PMID: 20657917.
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Lentiviral vectors for immune cells targeting. Immunopharmacol Immunotoxicol.
Immunopharmacol Immunotoxicol . 2010 Jun; 32(2):208-18.
Froelich S, Tai A, Wang P.
PMID: 20085508.
Targeting lentiviral vector to specific cell types through surface displayed single chain antibody and fusogenic molecule.
Virol J. 2010 Feb 11; 7:35.
Lei Y, Joo KI, Zarzar J, Wong C, Wang P.
Protein nanocapsule weaved with enzymatically degradable polymeric network.
Nano Lett . 2009 Dec; 9(12):4533-8.
Gu Z, Yan M, Hu B, Joo KI, Biswas A, Huang Y, Lu Y, Wang P, Tang Y.
PMID: 19995089.
Nonintegrating lentiviral vectors can effectively deliver ovalbumin antigen for induction of antitumor immunity.
Hum Gene Ther. 2009 Dec; 20(12):1652-64.
Hu B, Yang H, Dai B, Tai A, Wang P.
PMID: 19663564.
HIV-1 Gag-specific immunity induced by a lentivector-based vaccine directed to dendritic cells.
Proc Natl Acad Sci U S A. 2009 Dec 01; 106(48):20382-7.
Dai B, Yang L, Yang H, Hu B, Baltimore D, Wang P.
PMID: 19918062.
Introduction of an aliphatic ketone into recombinant proteins in a bacterial strain that overexpresses an editing-impaired leucyl-tRNA synthetase.
Chembiochem. 2009 Sep 04; 10(13):2188-90.
Tang Y, Wang P, Van Deventer JA, Link AJ, Tirrell DA.
PMID: 19670197.
Targeted gene delivery to CD117-expressing cells in vivo with lentiviral vectors co-displaying stem cell factor and a fusogenic molecule.
Biotechnol Bioeng. 2009 Sep 01; 104(1):206-15.
Froelich S, Ziegler L, Stroup K, Wang P.
PMID: 19452500.
Pulsatile shear stress increased mitochondrial membrane potential: implication of Mn-SOD.
Biochem Biophys Res Commun .2009 Oct 16; 388(2):406-12.
Li R, Beebe T, Cui J, Rouhanizadeh M, Ai L, Wang P, Gundersen M, Takabe W, Hsiai TK.
PMID: 19666009.
Engineering fusogenic molecules to achieve targeted transduction of enveloped lentiviral vectors.
J Biol Eng. 2009 Jun 02; 3:8.
Lei Y, Joo KI, Wang P.
PMID: 19490632.
Cell type-specific targeting with surface-engineered lentiviral vectors co-displaying OKT3 antibody and fusogenic molecule.
Pharm Res. 2009 Jun; 26(6):1432-45.
Yang H, Joo KI, Ziegler L, Wang P.
PMID: 19259792.
In vitro differentiation of adult bone marrow progenitors into antigen-specific CD4 helper T cells using engineered stromal cells expressing a notch ligand and a major histocompatibility complex class II protein.
Stem Cells Dev. 2009 Mar; 18(2):235-45.
Dai B, Wang P.
PMID: 18680390.
Engineering human hematopoietic stem/progenitor cells to produce a broadly neutralizing anti-HIV antibody after in vitro maturation to human B lymphocytes.
Blood. 2009 Feb 12; 113(7):1422-31.
Luo XM, Maarschalk E, O'Connell RM, Wang P, Yang L, Baltimore D.
PMID: 19059876.
Gamma-retroviral vectors enveloped with an antibody and an engineered fusogenic protein achieved antigen-specific targeting.
Biotechnol Bioeng. 2008 Oct 01; 101(2):357-68.
Yang H, Ziegler L, Joo KI, Cho T, Lei Y, Wang P.
PMID: 18435481.
Targeting lentiviral vectors to antigen-specific immunoglobulins.
Hum Gene Ther. 2008 Sep; 19(9):861-72.
Ziegler L, Yang L, Joo Ki, Yang H, Baltimore D, Wang P.
PMID: 18590376.
Site-specific labeling of enveloped viruses with quantum dots for single virus tracking.
ACS Nano. 2008 Aug; 2(8):1553-62.
Joo KI, Lei Y, Lee CL, Lo J, Xie J, Hamm-Alvarez SF, Wang P.
PMID: 19079775.
CD4+CD25- T cells transduced to express MHC class I-restricted epitope-specific TCR synthesize Th1 cytokines and exhibit MHC class I-restricted cytolytic effector function in a human melanoma model.
J Immunol. 2008 Jul 15; 181(2):1063-70.
Chhabra A, Yang L, Wang P, Comin-Anduix B, Das R, Chakraborty NG, Ray S, Mehrotra S, Yang H, Hardee CL, Hollis R, Dorsky DI, Koya R, Kohn DB, Ribas A, Economou JS, Baltimore D, Mukherji B.
PMID: 18606658.
Visualization of targeted transduction by engineered lentiviral vectors.
Gene Ther. 2008 Oct; 15(20):1384-96.
Joo KI, Wang P.
PMID: 18480844.
Engineered lentivector targeting of dendritic cells for in vivo immunization.
Nat Biotechnol. 2008 Mar; 26(3):326-34.
Yang L, Yang H, Rideout K, Cho T, Joo KI, Ziegler L, Elliot A, Walls A, Yu D, Baltimore D, Wang P.
PMID: 18297056.
Targeting lentiviral vectors to specific cell types in vivo.
Proc Natl Acad Sci U S A. 2006 Aug 01; 103(31):11479-84.
Yang L, Bailey L, Baltimore D, Wang P.
PMID: 16864770.
